| 一株子囊菌次生代谢产物及其抗HIV活性的研究 |
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| 引用本文： | 邹先伟,孙炳达,陈绪林,刘杏忠,车永胜.一株子囊菌次生代谢产物及其抗HIV活性的研究[J].中国天然药物,2009(2):140-144. |
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| 作者姓名： | 邹先伟 孙炳达 陈绪林 刘杏忠 车永胜 |
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| 作者单位： | [1]中国科学院微生物研究所中国科学院真菌地衣系统学重点实验室,北京100190 [2]中国科学院研究生院,北京100039 [3]中国科学院武汉病毒研究所病毒学国家重点实验室,武汉430071 |
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| 基金项目： | 科技部863重点项目（No.2007AA021506）;中国科学院重要方向性项目（No.KSCX2-Y-G-013）. |
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| 摘 要： | 目的：从子囊菌中寻找抗HIV-1活性的新结构化合物。方法：应用硅胶VLC，Sephadex LH-20及反相HPLC分离化合物，根据MS，NMR等光谱技术鉴定了平面结构，并通过CD手性激子方法测定了绝对立体化学。结果：分离得到3个azaphilone类化合物，分别命名为helotialins A—C（1-3）。结论：化合物1-3为新化合物，化合物1和2具有中等的抗HIV-1活性。
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| 关 键 词： | Helotialean Fungus Ascomycete Azaphilone Anti—HIV-1 |
Helotialins A-C,Anti-HIV Metabolites from a Helotialean Ascomycete |
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| ZOU Xian-Wei,SUN Bing-Da,CHEN Xu-Lin,LIU Xing-Zhong,CHE Yong-Sheng.Helotialins A-C,Anti-HIV Metabolites from a Helotialean Ascomycete[J].Chinese JOurnal of Natural Medicines,2009(2):140-144. |
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| Authors: | ZOU Xian-Wei SUN Bing-Da CHEN Xu-Lin LIU Xing-Zhong CHE Yong-Sheng |
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| Institution: | 1Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190; 2Graduate School of Chinese Academy of Sciences, Beijing 100039; 3State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China) |
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| Abstract: | AIM： To search for anti-HIV-1 metabolites from the cultures of helotialean ascomycete. METHODS： Helotialins A-C （1-3） were purified from the crude extract using silica gel VLC, Sephadex LH-20 column chromatography, and reversed-phase HPLC. The structures of 1-3 were determined by NMR spectroscopy, and their absolute configurations were assigned by CD excitation chirality method. RESULTS： Helotialins A-C （1-3） were identified as three new azaphilone analogues. CONCLUSION： Compounds I and 2 displayed inhibitory effects on HIV-1 replication in C8166 cells. |
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| Keywords: | Helotialean Fungus Ascomycete Azaphilone Anti-HIV-1 |
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