两种八角属木兰科植物提取物抗炎镇痛作用的比较

目的：由于狭叶茴香属于我国的濒危野生物种之一,寻找狭叶茴香的理想替代药材非常必要。本研究的目的是比较狭叶茴香和假地枫皮这两种八角属植物的根皮提取物注射液的抗炎镇痛作用。方法：本实验采用大鼠角叉菜胶足跖肿胀模型,小鼠耳廓二甲苯致炎模型以及醋酸引起的小鼠腹腔毛细血管通透性模型评价这两种注射液的抗炎活性。小鼠热板致痛模型和小鼠醋酸致痛模型评价这两种注射液的镇痛活性。结果：这两种注射液均表现出显著的抗炎镇痛作用。实验结果中没有出现显著性差异。结论：假地枫皮的根皮提取物注射液的抗炎镇痛作用与狭叶茴香的相当。实验结果显示,假地枫皮有可能成为狭叶茴香的理想替代药材。

Anti-inflammatory and Analgesic Effects of Two Extracts Isolated from Illicium

AIM： Since lllicium lanceolatum A. C. Smith is one of the endangered wildlife in China, searching for its substitutes is quite necessary. The aim of our study was to compare the anti-inflammatory and analgesic effects of two injections of extracts isolated from the root bark of lllicium angustisepalum A. C. Smith and lllicium Jiadifengpi B.N. Chang, respectively. METHODS： Rat paw oedema and mice ear edema test, as well as acetic acid-induced vascular permeability, were used to evaluate the anti-inflammatory activity between the two injections. Hot-plate test and acetic acid-induced writhing test were used to determine analgesic effects between the two injections. RESULTS： Both injections displayed marked anti-inflammatory and analgesic effects. No significant difference between the two injections was seen according to the statistical data. CONCLUSION： The injection of extract isolated from the root bark of lllicium Jiadifengpi B.N. Chang has better anti-inflammatory and analgesic effects to lllicium angustisepalum A. C. Smith. The results indicate that lllicium Jiadifengpi B.N. Chang might possibly be used as a substitute of lllicium angustisepalum A. C. Smith.