| 改性壳聚糖在药物传递中的应用进展 |
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| 引用本文： | 吴晓莉,张灿,平其能. 改性壳聚糖在药物传递中的应用进展[J]. 中国天然药物, 2009, 0(6): 458-464 |
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| 作者姓名： | 吴晓莉 张灿 平其能 |
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| 作者单位： | 中国药科大学药学院,南京210009 |
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| 基金项目： | 教育部新世纪人才基金（No.NCET-06-0499）;教育部重点项目（No.107062） |
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| 摘 要： | 天然聚合物壳聚糖优良的可生物相容和生物降解性，以及独特的荷正电性使其受到研究者的广泛关注。为了解决壳聚糖的溶解性和增加其药用功能性，研究人员设计合成了一系列壳聚糖衍生物。本文综述了近年来化学改性的壳聚糖在药物传递系统中的应用。
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| 关 键 词： | 壳聚糖衍生物 胶束 基因载体 靶向 口服 智能材料 |
Progress on Modified Chitosan Applied in Drug Delivery System |
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| WU Xiao-Li,ZHANG Can,PING Qi-Neng. Progress on Modified Chitosan Applied in Drug Delivery System[J]. Chinese JOurnal of Natural Medicines, 2009, 0(6): 458-464 |
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| Authors: | WU Xiao-Li ZHANG Can PING Qi-Neng |
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| Affiliation: | ( School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | In the fields of drug delivery system, much attention has been focused on chitosan, which is biocompatible, biodegradable, and positive charge carrying, while the poor solubility in water limits its wide use. To improve its solubility and function, varities of chitosan derivatives have been synthesized. This article reviews the applications of modified chitosan in drug delivery system. |
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| Keywords: | Chitosan derivatives Micelles Gene carrier Target Oral Smart material |
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