IL-10基因启动子多态性与小儿哮喘的相关性

目的探讨白细胞介素-10（IL-10）基因多态性、等位基因在儿童哮喘发病机制中的意义。方法采用顺序特异引物聚合酶链反应方法（PCR-SSP）对30例小儿哮喘病儿（哮喘组）及26例非哮喘呼吸道疾病患儿（非哮喘组）作IL-10基因多态性分析。结果两组IL-10基因型、单体型频率、等位基因频率比较，差异均无统计学意义。结论本研究未能证实小儿哮喘易感性与IL-10基因启动子位点上多态性相关联。

Lack of association between childhood asthma and interleukin - 10 polymorphism gene

Objective To investigate the association of the polymorphism in the promter of interleukin-10 gene with childhood asthma.Methods In two groups,childhood asthmatics and childhood control groups with no personal or family history of asthma,were genotyped for IL-10 by a PCR-SSP approach.The relative frequency of-1082G/A,-819C/T and-592C/A alleles in childhood control groups(n=26) and childhood asthmatics(n=30) was compared.Results There was no singnificant difference in the frequencies of IL-10 genotypes,haplotype and alleles between the asthma group and the control group.Conclusion The polymorphism in the promoter of IL-10 gene does not confer a susceptibility to develop childhood asthma.