Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain |
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| Authors: | V. V. Grigoriev L. N. Petrova A. V. Gabreliyan T. A. Ivanova |
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| Affiliation: | (1) Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow region, Russia |
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| Abstract: | We studied the effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors. L,D-Dipeptide more potently than L,L-dipeptide inhibited postsynaptic NMDA receptors, potentiated GABA and AMPA receptors, and inhibited 45Ca2+ uptake in synaptosomes from of rat brain cortex. Our results indicate that muramyl dipeptides modulate function of glutamate and GABA receptors. Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 146, No. 9, pp. 247–249, September, 2008 |
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| Keywords: | muramyl dipeptides receptors synaptosomes calcium |
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