大鼠阴茎组织NOS活性对雄激素的依赖性

目的探讨ＮＯＳ活性与雄激素在阴茎勃起中的关系。方法将３０只成年雄性大白鼠随机分为去势组，替代组及对照组，去势组与替代组分别切除双侧睾丸，其中替代组在切除睾丸后给予睾酮替代。于术后１周取阴茎组织，用紫外分光光度法检测其ＮＯＳ活性。结果去势组ＮＯＳ活性较对照下降７０％（Ｐ＜０．０１），睾酮替代组和对照组ＮＯＳ活性差异无显著性（Ｐ＞０．０５）。结论雄激素可能通过调节ＮＯＳ活性而在阴茎勃起中发挥重要作用。

Androgen dependence of NOS activity in rat penile tissue

Objective To investigate whether the NOS activity is associated with androgen in penile erection. Methods Thirty mature male rats were randomly divided into 3 groups:unoperated controls,castrates,castrates given testosterone (T) replacement. One week after castration,NOS activity in penile tissue were detected with ultraviolet spectrophotometry. Results The NOS activity in controlscastrates and castrates with T replacement was (1.440.37)nmolg-1min-1(0.43 0.31)nmolg-1min-1 and (1.370.37)nmolg-1min-1, respectively. Compared with controls, the NOS activity in castrates decreased by 70%(P<0.01).But there is no significant difference in NOS activity between controls and castrates with T replacement(P>0.05). Conclusions It was suggested that androgen plays an important role on penile erection through regulating NOS activity.