糖尿病性阴茎勃起功能障碍大鼠模型海绵体超微结构的研究

目的　探讨糖尿病（ＤＭ） 性阴茎勃起功能障碍（ＥＤ） 的发病机理。　方法　ＳＤ 大鼠注射链脲佐菌素制造ＤＭ 动物模型后，注射阿朴吗啡观察６ 周、８ 周及１２ 周大鼠阴茎勃起情况，筛选ＤＭ 性ＥＤ 大鼠模型，观察其阴茎海绵体组织超微结构的改变。　结果　ＤＭ 性ＥＤ 大鼠模型阴茎海绵体内皮细胞及平滑肌细胞超微结构均有明显的病理改变：线粒体退变、内质网扩张，糖原颗粒、吞饮小泡及微丝减少。此外，还可见大量间质组织增生及微血管腔闭塞。随ＤＭ 病程不同，其改变程度不同，８ 周时以内皮细胞损害为明显，１２ 周时以平滑肌细胞损害为明显。　结论　ＤＭ 严重影响阴茎勃起功能，海绵体组织超微结构的病理改变可能是ＤＭ 性ＥＤ 发病机理之一。

Ultrastructual studies of cavernous tissue in impotent rats with diabetes mellitus

Objective To study the ultrastructure of cavernous tissue in impotent rats with diabetes mellitus (DM). Methods Sprague Dewley rats were injected intraperitoneally with streptozotocin(STZ) to make experimental models of DM.Injected with apomorphine,penile erections in rats with DM and in controls were observed and noted on the sixth week,the eighth week and the twelfth week from the fourth day of injecting STZ.The experimental models of impotent rats with DM were then selected and the ultrastructure of the cavernous tissues studied. Results The significant pathological changes were observed in the endothelial and smooth muscle cells of cavernous tissue of impotent rats with DM:these were the degeneration of mitochondria,the dilatation of endoplasmic reticulum,the reduce of glycogen particle,pinocytotic vesicle and microfilament.The proliferation of messenchymal tissue and obturation of microvessel were also observed.The change extent of cavernous tissue was positively correlated with the duration of DM,the changes of endothelial and smooth muscle cells being obvious on the eight or twelve week. Conclusions The function of penile erection is affected seriously by DM,and these pathological changes of cavernous tissue may be one of the most important mechanisms of impotence with DM.