神经节苷脂GM_1治疗新生儿缺氧缺血性脑病

目的：探讨神经节苷脂GM1对于新生儿缺氧缺血性脑病的治疗效果。方法：收集患有缺血缺氧性脑病的新生儿120例,随机分为治疗组和对照组各60例。1个疗程后评价治疗效果、脑CT变化、检查血清超氧物歧化酶及血清丙二醛水平及进行新生儿行为神经评分。结果：治疗组总有效率为96.67%,对照组为65.0%,两者比较差异有统计学意义（P〈0.05）。结论：对于中重度新生儿缺氧缺血性脑病患儿,在常规治疗的基础上应用神经节苷脂GM1治疗,疗效显著,安全可靠。

GM1 ganglioside treatment of neonatal hypoxic ischemic encephalopathy

Objective To study the ganglioside GM1 for neonatal hypoxic ischemic encephalopathy treatment.Methods With hypoxic ischemic encephalopathy in newborns 120 cases were randomly divided into treatment group and control group 60 cases.A course of treatment after the evaluation,brain CT changes,check the serum superoxide dismutase and serum malondialdehyde levels and neonatal behavioral neurological assessment.Results The total effective rate was 96.67%,65.0% in the control group,the difference was statistically significant.Conclusion For moderate to severe hypoxic ischemic encephalopathy,in the conventional treatment based on the application of GM1 ganglioside treatment of known efficacy,safety and reliability.