超敏C-反应蛋白与脑梗死短期预后的关系

目的:探讨脑梗死患者发病后7～10d血清超敏C-反应蛋白(High-sensitivityCRP)水平与脑梗死短期预后的关系。方法:收集初次发病的脑梗死患者发病后7～10d血清超敏C-反应蛋白(hs-CRP)浓度及临床资料,出入院时采用美国国立卫生研究院卒中量表(NIHSS)评分评价神经功能,随访新发心脑缺血事件的发生,比较高、低hs-CRP组的预后,并进行多因素分析了解hs-CRP与脑梗死预后的关系。结果:115例脑梗死患者完成随访,其中57例患者hs-CRP>3mg/L,与58例低hs-CRP组比较,其出院时NIHSS评分较高[(5.56±4.28)vs(3.41±3.14),P=0.003],随访约10个月后其新发心脑缺血事件发生率较高且独立相关(17.5%vs5.2%,P=0.036;OR值=2.211,P=0.019)。结论:超敏C-反应蛋白与脑梗死的短期预后相关,可能是脑梗死患者短期神经功能恢复较差及新发心脑缺血事件发生率较高的一种独立预测因子。

Clinical study on the relationship between high-sensitivity C-reactive protein and prognosis of cerebral infarction

Objective To investigate the relation between the serum high-sensitivity C-reactive protein level on 7～10 d after the onset of cerebral infarction and the prognosis in patients with cerebral infarction.Methods Patients who were first diagnosed as cerebral infarction in our hospital were recruited in our study.Serum hs-CRP was examined on 7～10 d after onset.NIHSS scores at discharge and incidence rate of new ischemic events were used to evaluate the prognosis of cerebral infarction.We examined the association between the level of hs-CRP and the prognosis.Results 115 patients were enrolled in our study among whom 57 patients were found with higher hs-CRP level.The patients with higher hs-CRP level had higher NIHSS scores[5.56±4.28）vs（3.41±3.14）,P=0.003]at discharge and higher incidence rate of new ischemic events after 10 months follow-up （17.5% vs 5.2%,P=0.036）.Hs-CRP is independently correlated with NIHSS scores at discharge and is an independent predictor of new ischemic events.Conclusion Hs-CRP is correlated with prognosis of cerebral infarction,and is a predictor for worse neurologic functional recovery and higher incidence rate of new ischemic events.