Differential G protein receptor kinase 2 expression in compensated hypertrophy and heart failure after myocardial infarction in the rat |
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Authors: | J Theilade C Strøm T Christiansen S Haunsø S P Sheikh |
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Institution: | (1) Laboratory for Molecular Cardiology, 20, Juliane Mariesvej, 2100 Copenhagen, Denmark. sheikh@molheart.dk, DK |
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Abstract: | The onset of heart failure is associated with characteristic changes in myocardial expression of G protein receptor kinase
2 (GRK2). Although, GRK2 significantly contributes to the regulation of myocardial function in the failing heart, the GRK2
expression during cardiac hypertrophy without heart failure remains to be explored. We here report a differential expression
of GRK2 in cardiac hypertrophy with or without heart failure in response to a myocardial infarction in the rat. Postmyocardial
infarction animals were divided into two groups depending on the absence or presence of pulmonary edema, which is a manifestation
of heart failure. Remarkably, cardiac GRK2 expression and activity were inhibited in animals with cardiac hypertrophy without
heart failure, whereas animals with heart failure had elevated GRK2. Thus, three weeks after the infarction cardiac GRK2 expression
in animals with hypertrophy alone was decreased to 0.34 of control, whereas in the group of animals with heart failure GRK2
expression was 1.89-fold higher than in sham-operated animals. GRK2 activity was affected in a similar way, three and nine
weeks after the infarction cardiac GRK2 activity was reduced to 0.58 and 0.62 in animals with hypertrophy without heart failure
when compared to sham operated animals. By contrast, GRK2 activity was increased by 1.32- and 1.21-fold three and nine weeks
postinfarction in animals with heart failure when compared to sham animals. These data suggest that GRK2 expression is differentially
regulated in hypertrophic, non-failing and hypertrophic, failing hearts.
Received: 26 August 2002, Returned for 1. revision: 9 September 2002, 1. Revision received: 25 September 2002, Returned for
2. revision: 24 October 2002, 2. Revision received: 3 November 2002, Accepted: 9 November 2002
Correspondence to: S. P. Sheikh |
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Keywords: | Myocardial infarction – heart failure – G receptor kinase 2 – wistar rats – desensitization |
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