血清尿酸水平与冠心病的关系探讨

目的探讨血清尿酸（SUA）水平与冠心病（CHD）的关系。方法 248例疑似冠心病患者,经冠状动脉造影分为冠心病组182例和非冠心病组66例;冠心病组分为单支病变组78例,双支病变组48例,三支病变组56例。测定血清尿酸（SUA）,同时记录年龄、性别、吸烟、高血压、糖尿病等相关因素。结果冠心病患者血清尿酸水平高于对照组（P〈0.01）,随着冠状动脉病变支数增加,血清尿酸水平明显增加（P〈0.05）;双支病变组、三支病变组血清尿酸均高于单支病变组。结论血尿酸水平升高可能是冠心病的危险因素,SUA水平可反映冠状动脉病变程度。

Study on the Relationship Between Serum Uric Acid and Coronary Heart Disease

Objective To study the relationship between serum uric acid（SUA）level and coronary heart disease（CHD）.Methods All of 248 patients with suspected CHD were divided into CHD group（182 cases）and control group（66 cases） according to the result of coronary angiographic examination.Serum uric acid were determined.The relative factors of CHD,such as age,gender,smoking,hypertension and diabetes mellitus were registered.Results The serum concentration of uric acid in CHD was higher than of control group（P0.01）;With the increasing of the numbers of stenosed branch,the serum concentration of uric acid increased significantly（P 0.05）;The serum concentration of total bilirubin uric acid in stenosis of two and three branchs of coronary artery groups were higher than that of stenosis of single branch of coronary artery group.Conclusion Elevated serum uric acid is a possible risk factor for coronary heart disease.SUA level could reflect coronary artery lesion degree.