化痰益气法联合莫西沙星对慢性阻塞性肺疾病急性加重期患者疗效及细胞因子、血液流变学的影响

目的 探讨化痰益气法联合莫西沙星对慢性阻塞性肺疾病(COPD)急性加重期患者疗效及细胞因子、血液流变学的影响.方法 70例COPD急性加重期患者随机分为对照组与研究组,每组35例.对照组给予莫西沙星治疗,研究组在莫西沙星治疗基础上结合化痰益气汤治疗,两组疗程均为10d.结果 研究组治疗10d总有效率高于对照组(91.43％ vs.62.86％)(P＜0.05);两组TNF-α和IL-18治疗10d后较治疗前下降(p＜0.05);研究组TNF-α和IL-18治疗10 d后低于对照组(P＜0.05);两组全血黏度高切、全血黏度低切、血浆黏度治疗10d后较治疗前下降(P＜0.05);研究组全血黏度高切、全血黏度低切、血浆黏度治疗10d后低于对照组(P＜0.05);两组FEV1、FEV 1/FVC治疗10 d后较治疗前增加(p＜0.05);研究组FEV1、FEV1/FVC治疗10d后高于对照组(P＜0.05);两组用药期间均未出现明显药物不良反应.结论 化痰益气法联合莫西沙星对COPD急性加重期患者疗效显著,可降低TNF-α和IL-18及改善血液流变学,值得进一步研究.

The clinical efficacy of Huatan and Boosting Qi therapy combined with moxifloxacin in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease and its effect on cytokine and hemorheology

Objective To investigate the clinical efficacy of Huatan and Boosting Qi therapy combined with moxifloxacin in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its effect on cytokine and hemorheology.Methods 70 cases of AECOPD were randomly divided into control group (n=35) and research group (n=35).Control group was treated with moxifloxacin,and research group was treated with Huatan and Boosting Qi therapy on the basis of the treatment in control group.Both group were treated for 10 d.Results The total effective rate in research group after 10 d of treatment was significantly higher than that in control group (91.43％ vs.62.86％,P＜0.05).The levels of TNF-α and IL-8 in both groups significantly decreased after 10 d of treatment (P＜0.05);the levels of TNF-α and IL-8 after 10 d of treatment in research group were significantly lower than those in control group (P＜0.05).High shear viscosity,low shear viscosity,and plasmic viscosity in both groups significantly decreased after 10 d of treatment (P＜0.05);high shear viscosity,low shear viscosity,and plasmic viscosity after 10 d of treatment in research group were significantly lower than those in control group (P＜0.05).The levels of FEV 1,FEV 1/FVC in both groups significantly increased after 10 d of treatment (P＜0.05);the levels of FEV1,FEV1/FVC after 10 d of treatment in research group were significantly higher than those in control group (P＜0.05).There were no obvious adverse drug reactions during the treatment course.Conclusions Huatan and Boosting Qi therapy combined with Moxifloxacin has striking effect in the treatment of patients with AECOPD,which can reduce TNF-α and IL-8,improve the hemorheology,worthy of further study.