瑞舒伐他汀对老年急性ST段抬高型心肌梗死冠脉介入治疗术后再狭窄的影响

目的 探讨瑞舒伐他汀对行经皮冠状动脉介入治疗(PCI)的老年急性ST段抬高型心肌梗死患者术后再狭窄的影响.方法 选取我院2014年6月至2015年9月收治的行PCI的老年急性ST段抬高型心肌梗死患者126例,将所有患者随机分为对照组和观察组,对照组患者术后给予口服阿托伐他汀钙治疗,观察组患者术后给予口服瑞舒伐他汀钙.每组63例.比较两组患者术后第1天和第1、3、6个月血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)水平的差异,并于术后6个月复查冠脉狭窄情况.结果 观察组患者术后第1、3、6个月血清总胆固醇水平分别为(4.17±0.75) mmol/L、(4.01±0.80) mmol/L、(4.02±0.77) mmol/L,明显低于对照组的(4.40±0.86)mmol/L、(4.37±0.81) mmol/L、(4.34±0.75) mmol/L,差异均有统计学意义(P＜0.05).观察组患者术后第1、3、6个月血清低密度脂蛋白胆固醇水平分别为(2.36±0.97) mmol/L、(2.23±0.86) mmol/L、(2.22±0.86) mmol/L,明显低于对照组的(2.59±0.92) mmol/L、(2.52±0.87) mmol/L、(2.48±0.81)mmol/L,差异均有统计学意义(P＜0.05).观察组患者术后1个月的血清高敏C-反应蛋白水平为(3.77±1.55) mg/L,明显低于对照组的(4.47±2.51) mg/L,差异有统计学意义(P＜0.05).观察组术后6个月再狭窄率为7.94％,明显低于对照组的1 1.11％,差异有统计学意义(P＜0.05).结论 瑞舒伐他汀与阿托伐他汀均可能够预防PCI术后冠脉炎性反应,但瑞舒伐他汀调节血脂水平效果更佳、抗炎效果更为迅速,且有效减少术后冠脉再狭窄的发生.

Effect of rosuvastatin on restenosis after percutaneous coronary intervention in elderly patients with ST-segment elevation myocardial infarction

Objective To investigate the effect ofrosuvastatin on restenosis after percutaneous coronary intervention (PCI) in elderly patients with ST-segment elevation myocardial infarction.Methods 126 elderly patients with ST-segment elevation myocardial infarction treated with PCI form June 2014 to September 2016 were randomly divided into control group and observation group,63 cases in each group.Control group was treated with atorvastatin calcium,while observation group was treated with rosuvastatin calcium.Compared the levels of serum total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),and high-sensitivity C-reactive protein (hs-CRP) at the first day and 1,3,6 months after operation of two groups,and evaluated coronary artery stenosis 6 months after operation.Results The level of serum TC in observation group 1,3,6 months after operation were (4.17±0.75) mmol/L,(4.01±0.80) mmol/L,(4.02±0.77) mmol/L,significantly lower than (4.40±0.86) mmol/L,(4.37±0.81) mmol/L,(4.34±0.75) mmol/L in control group (P＜0.05).The level of serum LDL-C in observation group 1,3,6 months after operation were (2.36±0.97) mmol/L,(2.23±0.86) mmol/L,(2.22±0.86) mmol/L,significantly lower than (2.59±0.92) mmol/L,(2.52±0.87) mmol/L,(2.48±0.81) mmol/L in control group (P＜0.05).The level of serum hs-CRP 1 month after operation in observation group was (3.77± 1.55) mg/L,significantly lower than (4.47±2.51) mg/L in control group (P＜0.05).The restenosis rate of observation group during 6 months after operation was 7.94％,significantly lower than 11.11％ of control group (P＜0.05).Conclusions Rosuvastatin and atorvastatin can prevent inflammatory response after PCI,but rosuvastatin has better effect on regulating blood lipid level and better anti-inflammatory effect,and can still reduce the incidence of coronary restenosis after operation.