食管小细胞癌临床病理及免疫组织化学研究

 目的 研究食管原发小细胞癌的临床病理特征及其组织发生。方法 采用免疫组织化学方法。结果 单纯小细胞癌7 例,中间细胞型4 例,混合型3 例。免疫组织化学上,细胞角蛋白阳性10 例,上皮膜抗原阳性12 例,NSE阳性13 例,嗜铬粘蛋白A阳性6 例,突触素阳性4 例。随访病例中6 例在半年内死亡。结论 本研究证明食管小细胞癌是一种高度恶性的肿瘤,组织发生上支持来自全能干细胞。

The Clinicopathology and Immunohistochemical Study of Esophagus Small Cell Carcinoma

Objective study the clinic pathological character and histogenesis of primary esophagus small cell cancer.Methods use the immunohistochemistry.Results 7 cases were pure small cell types,4 intermediate types,3 combined types.Immunohistochemically,ten cases showed positive immunoreaction to cytokeratin.EMA.NSE.Chromogranin A Synaptophysin 12.13.6.4 cases,respectively.Among the patients which obtained follow have 6 case died within half year.Conclusion this study indicate that small cell carcinoma of esophagus is highly malignancy,support its histogenesis may origin from the multipotent stem cells.