P53、Bcl-2、P16和c-myc在卵巢上皮性肿瘤中的表达及意义

 目的 研究P53、Bcl-2、P16和c－myc基因在卵巢上皮性肿瘤中的意义。方法 采用免疫组织化学法（SABC法）对80例良性、26例交界性和116例恶性卵巢上皮性肿瘤P53、Bcl-2、P16和c-myc癌基因的表达情况进行检测。结果 P53、Bcl-2、P16和c－myc表达率分别为36．48％、27．47％、83．33％和52．25％,P53、Bcl-2、c-myc表达随恶性程度增加而增高,良恶性之间表达差异有显著意义（P＜0．01）,P16随恶性程度增高表达率降低,恶性和良队间表达差异有显著性（P＜0．01）,恶性肿瘤中的P53\、Bcl-2和c－myc随分期增加,表达增加。结论 四种癌基因在卵巢上皮性肿瘤中高表达或表达失调,良恶性之间表达差异有显著意义,表明它们在卵巢上皮性肿瘤发生、发展中起重要作用。

Expression of P53.Bcl-2.P16 and c-myc Genes in OvarianEpithelial Tumors

Objective To investigate expression of P⁵³.Bcl-2.P¹⁶ and c-myc genes in ovarian epithelial tumors and relationship between expression and genesis and prognosis and its role.Methods Application Immunohistochemistic Methods,studied expression of P⁵³.Bcl-2.P¹⁶ and c-myc genes in ovarian epithelial tumors included 80 cases benign.26 borderline and 116 malignant tumors.Results expression on rates of P⁵³.Bcl-2.P¹⁶ and c-myc were36.48%,27.4%,83.33% and 52.25% respectively.The expression of c-myc was increased with malignancy high,It has significant different between benign and malignant(P＜0.01).The expression rate of P¹⁶ was decreased with malignancy high and it has significance concern with tumor behavior(P＜0.01).The expression of P⁵³.Bcl-2 and c-myc in ovarian malignant tumor were related to the stage.