| 小儿非何杰金淋巴瘤P53基因突变与预后的研究 |
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| 引用本文： | 孙圣荣,李志华,涂毅,刘学锋.小儿非何杰金淋巴瘤P53基因突变与预后的研究[J].肿瘤防治研究,1999,26(4):270-271. |
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| 作者姓名： | 孙圣荣 李志华 涂毅 刘学锋 |
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| 作者单位： | 1. 湖北医学学附一院普外科, 耳鼻喉科, 武汉 430060;
2. 湖北医科大学病毒研究所 |
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| 摘 要： | 目的: 探讨小儿非何杰金淋巴瘤(NHL)P53基因突变与预后的关系。方法: 31例颈部与腹部Ⅱ、Ⅲ期NHL 患儿, 应用PCR-SSCP技术检测石腊标本中P53基因第5-6外显因子, 并对31例患者进行了近8年的随访。结果: 31例中11例存在着P53基因突变, 此11例中有7例复发。而无P53基因突变20例中仅1例复发。结论: 说明小儿NHL中P53基因突变是不良预后的指标, 与早期复发有关。
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| 关 键 词： | 淋巴瘤 NHL p53基因 基因突变 预后 儿童 |
The Research of the Relation between the Gene Mutation of P53 and Prognosis in Pediatric Non-Hodgkin Lymphoma |
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| SUN Shen rong,LI Zhi hua,TU Yi,et al General Surgery.The Research of the Relation between the Gene Mutation of P53 and Prognosis in Pediatric Non-Hodgkin Lymphoma[J].Cancer Research on Prevention and Treatment,1999,26(4):270-271. |
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| Authors: | SUN Shen rong LI Zhi hua TU Yi General Surgery |
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| Institution: | General Surgery Department, The first Affiliated Hospital of Hubei Medical University, Wuhan 430060 |
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| Abstract: | Objective: To explore the relation between the Gene Mutation of P53 and Prognosis in pediatric Non-Hodgkin Lymphoma. Methods: To detect the 5 -6 exon of P53 gene in 31 Ⅱ-Ⅲ phases pediatric Non-Hodgkin Lymphoma patients by PCR-SSCP technique and follow-up study them for 8 years. Results: The gene mutation of P53were found in 11 children (11/31)and the recurrecewere observed in 7 of them. The recurrece was only observed in 1 patient of 20 children without gene mutation of P53. Conclusion: The gene mutation of P53 is one of the indicators of prognosis in pediatric Non-Hodgkin Lymphoma and is related with recurrence in early stage. |
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| Keywords: | pediatric Non Hodgkin Lymphoma P 53 gene PCR SSCP |
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