阿立哌唑单药及联合舍曲林治疗强迫症的对照研究

目的：比较单用阿立哌唑与阿立哌唑联合舍曲林治疗强迫症的疗效及安全性。方法：将符合精神障碍诊断与统计手册第四版（DSM-IV）强迫症诊断标准的患者43例随机分为单药组和联药组。单药组21例,采用单一阿立哌唑治疗;联药组22例,采用阿立哌唑联合舍曲林治疗,疗程均为12周。应用耶鲁布朗强迫量表（Y-BOCS）和副作用量表（TESS）于治疗前及治疗后2、4、8、12周末评价其疗效及副作用。结果：单药组治疗第4周末Y-BOCS评分与治疗前相比差异有显著性意义（P〈0.05）。联药组治疗第2周末Y-BOCS评分与治疗前相比差异有显著性意义。单药组总有效率为52.4%,联药组总有效率为68.1%,两组比较差异有显著性意义（χ^2=8.822,P〈0.05）。两组副作用均较轻。结论：阿立哌唑可单独治疗强迫症,如联合SSRI药物疗效更佳。

A control study of Aripiprazole and Aripiprazole combined with Sertraline in the treatment of obsessive - compulsive disorder

ObJective ：To explore the efficacy and safety of Afipiprazole and Afipiprazole combined with Sertraline in the treatment of obsessive-compulsive disorder. Metilods：43 patients met the DSM-IV criteria for OCD were randomly divided into single drug group （n = 21 ） and combined drug group（ n = 22 ）, the single drug group was given Aripiprazole, combined drug group was given Aripiprazole combined with Sertraline, treatment for 12 weeks. The efficacy and side effects were assessed with Yale Brown Obsessive Compulsive Scale （ Y - BOCS） and Treatment Emergent Symptom Scale （TESS） before treatment and at the 2 nd ,4th, 8 th, 12th weekend. Results：The total scores of Y - B OCS decreased significantly at 4th weekend in the single drug group（ P 〈 0.05 ）. The totle scores of Y - BOCS decreased significantly at 2^nd weekend in the combined drug group. The total effective rate of the sin-gle drug group was 52.4%, the total effective rate of the combined drug group was 68.1% , there were significant differences between the two groups （ P 〈 0. 05 ）. Conclusion： Aripiprazole can be used alone to treat obsessive-compulsive disorder, but combined with SSRI has better efficacy.