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Substance P innervation of neurons projecting to the paraventricular hypothalamic nucleus in the rat nucleus tractus solitarius |
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| Authors: | Hitoshi Kawano Sadahiko Masuko |
| Affiliation: | Department of Anatomy, Saga Medical School, Nabeshima 5-1-1, Saga 849, Japan |
| Abstract: | After injection of WGA-HRP-colloidal gold in the rat paraventricular nucleus (PVN), retrogradely labeled neurons were found mainly in the medial and commissural subnuclei of the nucleus tractus solitarius (NTS) around 0.5 mm caudal to the obex which is closely related to cardiovascular function. Electron microscopic immunohistochemistry in these areas demonstrated synaptic contacts between retrogradely labeled neurons and substance P-immunoreactive terminals. Innervation of NTS-PVN projection systems by substance P is suggested. |
| Keywords: | Substance P Synapse Nucleus tractus solitarius Paraventricular hypothalamic nucleus WGA-HRP-colloidal gold Retrograde tract tracing Immunohistochemistry Electron microscopy |
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