新型异种块型植骨材料修复前臂节段性骨缺损

目的：观察分析新型异种块型植骨材料对前臂节段性骨缺损的治疗效果。及其临床应用方法。方法：对12例前臂外伤性骨缺损者采用新型异种块型植骨材料进行治疗。新型异种块型植骨材料由脱肮原大块牛松质骨载体与重组人骨形态发生蛋白2（rhBMP2)复合而成，评价其临床治疗效果。结果：随访8－36个月，平均16．5个月，所有病例均获骨性愈合，平均愈合时间5．5个月，术后无免疫排斥，感染、骨不连、畸形愈合和再发骨折等并发症，治疗效果优6例，良3例，可3例，优良率75％，植骨术后7、14和21d流式细胞仪检测，发现外周血T淋巴细胞亚群与术前及自体骨移植组相比无明显差异（P＞0．05）。结论：新疆异种块型植骨材料为自体骨和同种异体骨的良好替代替材料，应用中无明显的免疫排斥反应，组织相容性良好。

Use of a New Massive Reconstituted Bone Xenograft for the Treatment of Nonunions of the Forearm with Segmental Bone Defect

Objective:To analyse the treatment effect of a new massive reconstituted bone xenograft(MRBX)for the treatment of nonunions of the forearm with segmental bone loss and investigate the method of clinical application.Methods:Between December 1997 and December 2000,12 cases of posttraumatic segmental bone defect of forearm were treated with MRBX material which was composed of massive antigen free bovine cancellous bone and rhBMP 2.The clinical and roentgenographic follow up data of fracture healing and immune reaction of implanted MRBX based on flow cytometry test were evaluated.Results:The average duration of follow up was 16.5 months.All patients achieved solid bone union at an average of 5.5 months.There were no immune rejection,infection,nonunion,malunion and refracture in this series.The clinical results were excellent in six patients,good in three patients,fair in three patients.The blood test with flow cytometry found that MRBX transplantation did not affect the T lymphocyte subsets at 7,14 and 21 days after operation.There were no statistical significant differences between T lymphocyte subsets of pre operation and of post operation,or between T lymphocyte subsets of MRBX and of autografts transplantation( P >0.05).Conclusion:The results suggest that this new MRBX seems to be a good substituting material for autogeneic bone and allogeneic bone in the treatment of bone defects.It possesses marked osteoconductivity and osteoinductivity without evoking an immune rejection and promotes fracture healing in clinical use.