Differential repair activity of human chromosomes

The frequency of radioactive label (³H-thymidine) incorporation in human lymphocyte chromosomes in the course of repair (extra) synthesis of DNA was assessed. Chromosomes 7, 12, and 21 were found to have a lower, and chromosome 22 a higher repair activity than was expected when a uniform incorporation of the label along the genome was hypothesized. Segments were detected that incorporated an increased number of labels in the course of extra DNA synthesis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 69–71, January, 1995 (Presented by R. V. Petrov, Member of the Russian Academy of Medical Sciences)