| 头孢泊肟酯高效液相色谱含量测定方法的改进 |
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| 引用本文： | 邓小煌,林朝霞,曾雪花,廖月明,陈学智.头孢泊肟酯高效液相色谱含量测定方法的改进[J].中国药房,2007,18(19):1489-1491. |
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| 作者姓名： | 邓小煌 林朝霞 曾雪花 廖月明 陈学智 |
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| 作者单位： | 1. 深圳市龙岗中心医院药剂科,深圳市,518116
2. 广东药学院药学系,广州市,510006 |
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| 基金项目： | 广东省深圳市科技局科研项目 |
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| 摘 要： | 目的:改进以高效液相色谱法测定头孢泊肟酯及其制剂含量的方法。方法:色谱柱为C18,流动相为甲醇-水(50∶50),流速为1.5mL.min-1,柱温为40℃,检测波长为235nm。结果:头孢泊肟酯的线性范围为25～150μg.mL-1(r=0.9999);平均回收率为98.56%(RSD=1.79%),样品平均含量为101.54%。结论:本方法简便、快速、准确、灵敏,可用于头孢泊肟酯及其制剂的含量测定。
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| 关 键 词： | 高效液相色谱法 头孢泊肟酯 胶囊 含量测定 |
| 文章编号： | 1001-0408（2007）19-1489-03 |
| 收稿时间： | 2006-06-07 |
| 修稿时间： | 2006-06-072006-08-14 |
Improvement in Assay of Cefpodoxime Proxetil by Modified HPLC |
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| DENG Xiaohuang,LIN Zhaoxia,ZENG Xuehua,LIAO Yueming,CHEN Xuezhi.Improvement in Assay of Cefpodoxime Proxetil by Modified HPLC[J].China Pharmacy,2007,18(19):1489-1491. |
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| Authors: | DENG Xiaohuang LIN Zhaoxia ZENG Xuehua LIAO Yueming CHEN Xuezhi |
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| Abstract: | OBJECTIVE:To modify the HPLC method for determining the contents of cefpodoxime proxetil and cefpodoxime proxetil capsules or suspension,and to compare it with the method of UV determination.METHODS:Column:ODS-C18,mobile phase:methanol-water(50∶50),flow rate :1.5mL·min-1,column temperature:40℃,detection wavelength:235nm.RESULTS:The standard curve was rectilinear when cefpodoxime proxetil was within the range of 25～150μg·mL-1(r=0.999 9).The average recovery rate was 98.56%(RSD=1.79%)and the average content of the samples was 101.54%.CONCLUSIONS:The method is simple,rapid,accurate and sensitive for determination of cefpodoxime proxetil and cefpodoxime proxetil capsules or suspension. |
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| Keywords: | HPLC Cefpodoxime proxetil Capsules Determination of content |
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