| 脑复康—胆碱制剂优化组合的探索 |
| |
| 引用本文： | 吴文瑶 金三九. 脑复康—胆碱制剂优化组合的探索[J]. 中国医药工业杂志, 1990, 21(3): 122-124 |
| |
| 作者姓名： | 吴文瑶 金三九 |
| |
| 作者单位： | 复旦大学，杭州医药工业研究所 上海 200433，杭州 |
| |
| 摘 要： | 在自行设计的多道穿梭测试系统内,使几个动物同步进行穿梭道音/电击条件性主动回避行为的学习试验,并固定药物总剂量,使一成分用量递减而另一成分相应增加。初步测得复合制剂中脑复康的含量减少时,仍出现同样程度的促智效应,而不出现胆碱的毒性。
|
| 关 键 词： | 脑复康 胆碱 复合制剂 药理 |
EXPLORATION OPTIMIZATION OF PIRACETAM-CHOLINE PREPARATION |
| |
| WU Wen-Yao,JING San-Jiu Fudan University,Shanghai , Hangzhou Institute of Pharmaceutical Industry. Hangzhou. EXPLORATION OPTIMIZATION OF PIRACETAM-CHOLINE PREPARATION[J]. , 1990, 21(3): 122-124 |
| |
| Authors: | WU Wen-Yao JING San-Jiu Fudan University Shanghai Hangzhou Institute of Pharmaceutical Industry. Hangzhou |
| |
| Affiliation: | WU Wen-Yao,JING San-Jiu Fudan University,Shanghai 200433, Hangzhou Institute of Pharmaceutical Industry. Hangzhou 310000 |
| |
| Abstract: | The shuttle voice/shock conditional active avoidance test wasconducted with multiple-passage shuttle meter, using 100 mg/kg total dose withdifferent ratio of two components. The preliminary research in mice showedwhen in the piracetam (P) -chloine (C) preparation the ratio of P and C was 1:1or 1:4, the efficacy was approximately the same as the 100 mg/kg of P, andno toxicity of C was observed. |
| |
| Keywords: | piracetam choline combination optimization shuttle voice/shock conditional active avoidance learning |
| 本文献已被 CNKI 维普 等数据库收录！ |
