缬沙坦干预非杓型高血压者恢复杓型血压昼夜节律后对血醛固酮水平的影响

目的：了解非杓型高血压患者进行药物干预以恢复其杓型血压昼夜节律，并观察节律改变后对血浆醛固酮水平的影响。方法：对杓型和非杓型两组原发性高血压患者分别给予缬沙坦160mg／d，观察对血压昼夜节律的影响，并监测用药前后血浆醛固酮水平的变化。结果：对杓型和非杓型高血压患者应用缬沙坦治疗前后收缩压及舒张压均有不同程度的下降，非杓型组夜间收缩压及舒张厍的下降值与杓型相比有统计学差异，出现了明显的昼夜节律，血浆醛固酮水平出现了统计学差异。结论：缬沙坦对非杓型高血压患者有良好的降压作用，并能恢复非杓型高血压患者的昼夜节律，向杓型血压变化。

Effect of circadian variability of dipper blood pressure induced by valsartan in patients with non-dipper essential hypertension on levels of aldosterone

AIM: To investigate the circadian variability of the dipper blood pressure induced by valsartan in patients with non-dipper essential hypertension,and to observe levels of aldosterone.METHODS: The patients were divided into dipper and non-dipper groups.All patients were treated with valsartan(160 mg/d).The variability of circadian blood pressure were observed,and the levels of plasma aldosterone were monitored,too.RESULTS: After the treatment with valsartan,the systolic and diatolic blood pressure in all patients,either dipper or non-dipper groups,were evidently reduced, especially,the patient with non-dipper essential hypertension had more significant improvement.The circadian variability was appeared.The levels of aldosterone had a significant difference.CONCLUSION: Valsartan has significant effects for the patients with non-dipper essential hypertension.It can induce a circadian variability and recover the dipper blood pressure from non-dipper blood pressure.