| 胰岛素样生长因子-2基因印迹模式异常与男性不育的关系 |
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| 引用本文： | 冷慧敏,周亮,钱卫平.胰岛素样生长因子-2基因印迹模式异常与男性不育的关系[J].生殖与避孕,2012,32(4):254-258. |
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| 作者姓名： | 冷慧敏 周亮 钱卫平 |
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| 作者单位： | 1. 北京大学深圳医院,深圳,518036;汕头大学医学院,汕头,515041
2. 北京大学深圳医院,深圳,518036 |
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| 基金项目： | 国家自然科学基金，深港创新圈计划，深圳市科技研发资金基础研究计划资助项目，1，广东省医学科研基金 |
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| 摘 要： | 印迹基因胰岛素样生长因子-2(insulin-like growth factor-2,IGF2)是最早发现的内源性印迹基因。IGF2基因的甲基化印迹模式异常是基因表观遗传学改变的重要表现。睾丸印迹基因IGF2/H19表观遗传学的改变(通常是指基因甲基化的异常)与精子整体情况差或男性不育有关。生精小管中IGF-2主要分布于生精细胞外,与相应的膜受体结合,通过一系列的信号转导,参与精子的分化和成熟。IGF2基因的印迹丢失使得IGF-2的表达增加,可能通过一定的机制抑制精子的分化和成熟。
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| 关 键 词： | 胰岛素样生长因子-2(IGF-2) 印迹机制 男性不育 信号通路 |
Relationship between Insulin-like Growth Factor-2 Imprinting Disorder and Male Infertility |
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| Hui-min LENG
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Liang ZHOU
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Wei-ping QIAN.Relationship between Insulin-like Growth Factor-2 Imprinting Disorder and Male Infertility[J].Reproduction and Contraception,2012,32(4):254-258. |
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| Authors: | Hui-min LENG Liang ZHOU Wei-ping QIAN |
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| Institution: | 1(1.Peking University Shenzhen Hospital,Shenzhen,518036)(2.Shantou University Medical College,Shantou,5150313) |
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| Abstract: | Insulin-like growth factor-2(IGF2) is the first gene discovered to be imprinted.The aberrance of IGF2 imprinting status is one of the epimutation.Poor semen parameters or male infertility is associated with epimutation(often hypermethylation) of IGF2/H19.IGF-2 is mainly present outside of spermatogenic cells.IGF-2 integrates with some special receptors,after the functioning of signaling molecule in cells,which results in signaling transmission within cells,then effectors regulate the maturational process of spermatozoa.Loss of imprinting of IGF2 is associated with an increase of IGF-2 expression that may subsequently play an important role in the onset of the spermatogenesis. |
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| Keywords: | insulin-like growth factor 2(IGF-2) imprinting mechanism male infertility signal pathway |
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