|
|||||
|
|
Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump |
|
| Authors: | Qin Xuan Poon Brian Kwong Justin Niles Denver Schmidt Byron Z Rajagopal Lakshmi Gantt Soren |
| Affiliation: | a Microbiology Laboratory, A9601, Seattle Children''s Hospital, 4800 Sand Point Way, NE, Seattle, WA 98105, USA b Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA, USA c Seattle Children''s Hospital Research Institute, Seattle Children''s Hospital, Seattle, WA, USA d Department of Pediatrics, Division of Infectious Diseases, University of Washington School of Medicine, Seattle, WA, USA |
| Abstract: | Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)LC gene not previously described in S. aureus. The native plasmids carrying vga(A)LC were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates. |
| Keywords: | Staphylococcus aureus Clindamycin Efflux pump |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |