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Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters |
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| Authors: | Klaus H Baumann Ludwig Kiesel Manfred Kaufmann Gunther Bastert Benno Runnebaum |
| Institution: | (1) Department of Gynaecology and Obstetrics, University of Heidelberg, Germany;(2) Present address: Dept. of Gynaecology and Obstetrics, University of Tuebingen, Schleichstr. 4, W-7400 Tuebingen, Germany;(3) Present address: Lombardi Cancer Research Center, Georgetown University Medical Center, S-174, Reservoir Rd. NW, 20007 Washington, DC, USA |
| Abstract: | Summary Gonadotropin-releasing hormone analogs (GnRH-A) have been added to the armentarium in the therapy of hormone-dependent breast cancer in premenopausal women. The effect of chronic GnRH-A-treatment in premenopausal women is based on the suppression of the hypothalamus-pituitary-ovarian axis and the reduction of sex-steroid serum levels. In addition, a number of experimental and clinical data have been accumulated indicating a direct action of GnRH-A on breast cancer cells and tissue. In this study we analyzed 235 human breast cancer biopsies for specific GnRH-A-binding. We demonstrate high affinity GnRH-A binding sites in human breast cancer tissues. The evaluation of clinical data showed no correlation of the level of GnRH-A-binding with classical tumor parameters. |
| Keywords: | breast cancer gonadotropin-releasing hormone-analog GnRH receptor |
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