噻唑烷二酮类药物治疗2型糖尿病的有效性及安全性

噻唑烷二酮类药物是一类新型的治疗2型糖尿病的药物,通过提高机体对胰岛素的敏感性来达到良好控制血糖的作用.噻唑烷二酮类药物还可以有效地降低2型糖尿病患者血中低密度脂蛋白胆固醇、C-反应蛋白、基质金属蛋白酶-9、纤溶酶原激活物抑制剂-11的水平等,提高高密度脂蛋白胆固醇水平,改善血管内皮功能,减少2型糖尿病患者发生心血管疾病的风险.噻唑烷二酮类药物不良反应发生率低,安全性良好.

Efficacy and safety of thiazolidinediones for the treatment of type 2 diabetes mellitus

The thiazolidinediones(TZDs) are a new class of pharmacological agents for the treatment of type 2 diabetes mellitus, which are very effective in glycaemic control by improvement of insulin sensitivity. In addition, TZDs reduce small, more dense low- density lipoprotein cholesterol, C-reactive protein, matrix metalloproteinase-9, plasminogen activator inhibitor type 1 protein levels, and increase high-density lipoprotein cholesterol level, and improve endothelial function, which may have important beneficial effects on overall cardiovascular risk in patients with type 2 diabetes mellitus. A lower incidence of adverse drug reaction and a higher degree of safety have been observed inTZDs