| IgA肾病患者IL—2的产生及IL—2受体的表达 |
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| 引用本文： | 董柯 陈香美. IgA肾病患者IL—2的产生及IL—2受体的表达[J]. 免疫学杂志, 1992, 8(4): 253-255 |
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| 作者姓名： | 董柯 陈香美 |
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| 作者单位： | 解放军总医院肾科 北京100853(董柯)，解放军总医院肾科 北京100853(陈香美) |
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| 摘 要： | 本文对IgA肾病(IgAN)外周血淋巴细胞白细胞介素2(IL-2)的产生、受体的表达及免疫球蛋白的产生进行了研究。结果发现:外周血淋巴细胞产生IL-2的活性明显增高,IL-2受体表达亦明显增强并伴有免疫球蛋白产生增多,提示IgAN存在着细胞免疫功能的紊乱。
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| 关 键 词： | 肾疾病 白细胞介素2 受体 |
Generation of Interleukin-2 and Expression of Interleukin-2 Receptor in the Patients with IgA Nephropathy |
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| Dong Ke , Chen Xiangmei. Generation of Interleukin-2 and Expression of Interleukin-2 Receptor in the Patients with IgA Nephropathy[J]. Immunological Journal, 1992, 8(4): 253-255 |
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| Authors: | Dong Ke & Chen Xiangmei |
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| Abstract: | We determined interleukin-2 receptor (IL-2R) on the surface of lymphocytes ,interleukin-2 (IL-2) bioactivity and immunoglobulins produced by periperal lymphocytes stimulated with PHA or PWM in 15 patients with IgA nephropathy (IgA-N),The results showed: (l)The production of IL-2 in the patients with IgA-N showed a distinct enhancement. (2)IL-2R on lymphocytes in IgA-N was higher than that in the controls. (3)Immunoglobulin (especially IgA) produced by lymphocytes increased in IgA-N patients. In conclusion, IL-2 may play an important role in the pathogenesis of IgA-N. |
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| Keywords: | IL-2 IL-2 receptor IgA nephropathy |
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