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| 乳果糖降低非酒精性脂肪性肝炎患者肠道通透性及血清内毒素水平 | |
| 引用本文： | 杨林辉,刘国栋,谭朝霞,陈东风.乳果糖降低非酒精性脂肪性肝炎患者肠道通透性及血清内毒素水平[J].胃肠病学和肝病学杂志,2012,21(6):564-566,569. |
| 作者姓名： | 杨林辉 刘国栋 谭朝霞 陈东风 |
| 作者单位： | 1. 武警重庆总队医院消化内科,重庆,400061 2. 中国人民解放军第三军医大学附属西南医院感染病研究所 3. 中国人民解放军第三军医大学附属大坪医院野战外科研究所消化内科 |
| 摘 要： | 目的探讨乳果糖对非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)患者肠道通透性的干预作用。方法选择健康正常成人30例作为正常对照组(A组),非酒精性脂肪性肝炎共60例,随机分为NASH对照组(B组)和乳果糖干预组(C组)各30例,其中C组给予乳果糖(10 mL/d)进行干预。检测所有被研究者的血清内毒素、二胺氧化酶(diamine oxidase,DAO)、D-乳酸及ALT的浓度。干预4周后,再次检测B、C两组的血清内毒素、二胺氧化酶(DAO)、D-乳酸及ALT的浓度。结果与A组比较,治疗前B、C两组内毒素、DAO、D-乳酸水平显著增高(P<0.01),B组干预前后比较,内毒素、DAO、D-乳酸及ALT水平无显著改变(P>0.05),而C组干预前后比较,内毒素、DAO、D-乳酸及ALT水平显著降低(P<0.01)。结论 NASH患者血清内毒素水平及肠道通透性增高,乳果糖可降低NASH患者肠道的通透性及血浆内毒素水平。 |
| 关 键 词： | 肠道通透性 非酒精性脂肪性肝炎 乳果糖 内毒素 |
Lactulose could decrease intestinal permeability and levels of serum endotoxin in patients with NASH |
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| YANG Linhui , LIU Guodong , TAN Zhaoxia , CHEN Dongfeng.Lactulose could decrease intestinal permeability and levels of serum endotoxin in patients with NASH[J].Chinese Journal of Gastroenterology and Hepatology,2012,21(6):564-566,569. | |
| Authors: | YANG Linhui LIU Guodong TAN Zhaoxia CHEN Dongfeng |
| Institution: | 1.Department of Gastroenterology,Chongqing Municipal Corps Hospital of Chinese People’s Armed Police Force,Chongqing 400061;2.Institute of Infectious Disease,Southwest Hospital,the Third Military Medical University;3.Department of Gastroenterology,Institute of Surgery Research,Daping Hospital,the Third Military Medical University,Chinese PLA,China |
| Abstract: | Objective To investigate intervention effect of lactulose on intestinal permeability in patients with nonalcoholic steatohepatitis(NASH).Methods Thirty healthy adults and sixty patients with NASH were divided into 3 groups: health group(group A),NASH control group(group B,30 patients) and lactulose treated group(group C,30 patients).Their serum endotoxin,diamine oxidase,D-Lactate and ALT levels were measured respectively.The group C was treated with lactulose(10 mL/d).After 4 weeks treatment,their serum endotoxin,diamine oxidase,D-Lactate and ALT levels were detected again in group B and C.Results Compared with group A,serum endotoxin,diamine oxidase and D-Lactate levels increased(P<0.01) in group B and C.Four weeks later,serum endotoxin,diamine oxidase,D-Lactate and ALT levels decreased remarkably(P<0.01) in group C,but they did not change obviously in group B(P>0.05).Conclusion Lactulose could effectively decrease intestinal permeability and levels of serum endotoxin in patients with NASH. |
| Keywords: | Intestinal permeability NASH Lactulose Endotoxin |
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