帕罗西汀对轻-中度溃疡性结肠炎伴焦虑/抑郁的疗效评价

目的评价帕罗西汀辅助治疗轻-中度溃疡性结肠炎伴焦虑/抑郁的疗效。方法将30例轻-中度溃疡性结肠炎(UC)伴焦虑/抑郁患者随机分成2组(每组15例),分别接受5-氨基水杨酸和5-氨基水杨酸+帕罗西汀治疗;所有患者治疗前后均进行临床活动指数(CAI)、内镜指数(EI)和焦虑/抑郁测试,并比较治疗后的改善情况。结果治疗后5-氨基水杨酸+帕罗西汀组的CAI(腹泻和腹痛)和焦虑/抑郁评分较5-氨基水杨酸组显著下降(P<0.05,P<0.001),而EI和其他表现与5-氨基水杨酸组无显著差异(P>0.05)。结论对于轻-中度UC伴焦虑/抑郁的患者,帕罗西汀能改善焦虑/抑郁,通过减轻腹泻和腹痛而促进临床缓解,可作为辅助用药之一,但对组织学表现无改善作用。

Efficacy assessment of paroxetine in the treatment of patients with mild-to-moderate ulcerative colitis accompanied with anxiety/depression

Objective To assess the efficacy of paroxetine in the adjuvant treatment of patients with mild-to-moderate ulcerative colitis(UC) accompanied with anxiety/depression.Methods 30 patients diagnosed with mild-to-moderate UC accompanied with anxiety/depression were assigned into two groups(15 ones in each group) randomly,and were treated with 5-aminosalicylic acid and 5-aminosalicylic acid combined with paroxetine,respectively.Clinical activity index(CAI),endoscopic index(EI),and anxiety/depression tests were performed before and after the treatment,and the efficacy of treatment was compared.Results The difference was significant between two groups with respect to CAI(diarrhea and abdominal pain) and anxiety/depression scoring after the treatment(P<0.05,P<0.001),but there was no difference with respect to EI and other items(P>0.05).Conclusion Paroxetine can improve anxiety/depression,and accelerate the clinical remission through attenuating diarrhea and abdominal pain.Therefore,it might be an adjuvant treatment for patients with mild-to-moderate UC accompanied with anxiety/depression.However,it can not improve the histologic appearance.