| 双环醇片治疗肾移植术后药物性肝损伤的疗效观察 |
| |
| 引用本文： | 胡小鹏,尹航,王玮,杨晓勇,任亮,刘航,车乐,张小东. 双环醇片治疗肾移植术后药物性肝损伤的疗效观察[J]. 胃肠病学和肝病学杂志, 2012, 21(4): 342-344 |
| |
| 作者姓名： | 胡小鹏 尹航 王玮 杨晓勇 任亮 刘航 车乐 张小东 |
| |
| 作者单位： | 首都医科大学附属北京朝阳医院泌尿外科,北京,100020 |
| |
| 摘 要： | 目的探讨双环醇片治疗肾移植术后药物性肝损伤的安全性和有效性。方法将80例肾移植术后出现药物性肝损伤的患者按照随机原则分为两组,双环醇治疗组和硫普罗宁治疗组各40例,在应用常规抗免疫排斥药物同时采用双环醇片或硫普罗宁片进行保肝治疗,连续用药4周。结果双环醇治疗组在肝功能与综合疗效改善方面明显优于硫普罗宁治疗组(P<0.01或0.05),未发现与研究药物明显相关的不良事件。结论双环醇片可有效治疗肾移植术后由抗免疫排斥药物引起的肝损伤,疗效确切,安全性好。
|
| 关 键 词： | 肾移植 肝损伤 双环醇 |
Therapeutic efficacy of bicyclol for the drug induced hepatic injury after renal transplantation |
| |
| HU Xiaopeng , YIN Hang , WANG Wei , YANG Xiaoyong , REN Liang , LIU Hang , CHE Le , ZHANG Xiaodong. Therapeutic efficacy of bicyclol for the drug induced hepatic injury after renal transplantation[J]. Chinese Journal of Gastroenterology and Hepatology, 2012, 21(4): 342-344 |
| |
| Authors: | HU Xiaopeng YIN Hang WANG Wei YANG Xiaoyong REN Liang LIU Hang CHE Le ZHANG Xiaodong |
| |
| Affiliation: | Department of Urology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China |
| |
| Abstract: | Objective To investigate therapeutic efficacy and safety of bicyclol for drug-induced hepatic injury after renal transplantation.Methods 80 patients after renal transplantation were randomly divided into two groups.The therapeutic group(n=40) were given bicyclol together with conventional medicine,and the control group received tiopronin tablets in addition to routine medication.The treatment period lasted for 4 weeks.Results For patients with drug induced hepatic injury after renal transplantation,bicyclol exhibited a clearly superior role in improving liver function and comprehensive therapeutic effect to tiopronin(P<0.01 or 0.05).No obvious drug-related adverse events were found.Conclusion Bicyclol can effectively improve hepatic injury induced by immunosuppressants. |
| |
| Keywords: | Renal transplantation Hepatic injury Bicyclol |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
