应用伊托必利治疗慢性便秘的疗效观察

目的探讨应用伊托必利治疗慢性便秘的疗效。方法对84例慢性便秘患者根据其病理生理特点分型(STC、OOC、MTC),并应用伊托必利治疗2周,观察疗效。结果①应用伊托必利治疗慢性便秘患者2周后胃肠传输时间(Gastrointestinal Tran-sit Time,GITT)缩短;②应用伊托必利治疗2周后便秘患者肛门直肠压力及感觉功能无显著性差异。③应用伊托必利治疗慢性便秘患者2周后,STC组各症状评分较治疗前降低;OOC组各症状评分较治疗前无变化,MTC组排便频率症状评分较治疗前降低,其余较治疗前无变化。结论应用伊托必利治疗慢传输型便秘较出口梗阻型及混合型便秘效果更好。

Effect of Itopride in treatment of chronic constipation patients

Objective To evaluate the efficacy of Itopride in treatment of chronic constipation patients.Methods Eighty-four consecutive patients with chronic constipation who had been divided into three groups(slow transit constipation,outlet obstructed constipation and mixed type constipation) according to their pathophysiological characteristics received treatments with Itopride for two weeks.The efficacy of treatment was determined and the causes of constipation were analyzed.Results GITT in chronic constipation patients after 2 weeks therapy were all shorter than pretreatment(P<0.05).There was no difference of anorectal motility and rectal visceral perception to balloon distention in patients with chronic constipation before and after 2 weeks therapy.The symptom scores of constipation in STC patients after 2 weeks therapy were all lower than pretreatment(P<0.05).The symptom scores of constipation in OOC patients after 2 weeks therapy had no difference than pretreatment(P>0.05).The symptom scores of constipation in STC patients after 2 weeks therapy were all lower than pretreatment(P<0.05).The scores of defecate frequence in MTC patients after 2 weeks therapy were lower than pretreatment(P<0.05),the others had no change.Conclusion The patients of STC benefited from the Itopride treatments significantly than OOC and MTC.