β地中海贫血患儿生长落后与甲状腺功能关系的探讨

为分析甲状腺功能状态在β地贫生长落后患儿中的变化，以探讨甲状腺功能在患儿生长的价值。我们对27例β地贫患儿（重型21例，中间型6例）进行了身高（H）、体重（W）、血红蛋白（Hb）、血清铁蛋白（SF）、三碘甲腺原氨酸（Ts）和甲状腺素（L4）的测定。结果患儿的H、W、Hb均低于正常儿（P＜0．05）；SF高于正常儿（P＜0．05）；Ts、T4在5岁以下组（20例）为正常（P＞0．05），在5岁以上组（7例）低于正常（P＜0．05）。我们认为β地贫患儿的生长落后与长期贫血有关，“甲低”为亚临床型，甲状腺激素水平的低下不仅是生长落后的加重因素。铁的长期沉积比单次检测更有意义。

EXPLORE THE RELATIONSHIP BETWEEN THE FAILED GROWTH AND THYROID FUNCTION IN PATIENTS WITH β-THALASSEMIA

Objective:analyse the variation of thyroid hormone in the failed growth in patients with β-thalassemia. explore the values of thyroid function in the failed growth. Methods:measured height, body weight and levels of hemoglobin (Hb)、serum ferritin (SF)、thyroid hormones. In 27 patients with β-thalassemia (21 Major, 6 intermedia). Results:Patient’s height、weight and their levels of Hb were lower than that of control(P＜0. 05). The SF was higher than that of control (P＜0. 05),The levels of thyroid hormones were normal in the group of patients less than 5 year-old. But it became lower in the eldly patients group. Conclusion:the failed growth in the patients with β-thalassemia might be the result of chronic anemia. Hypothyroidism in the patients was in the Sub-clinic type. It was the avaggrate factor only on failed growth in the patients. The long-term accumulation of iron in the body was more important than the single detection of SF.