Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y |
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Authors: | Painsipp Evelin Herzog Herbert Sperk Günther Holzer Peter |
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Institution: | 1Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria;2Neurobiology Research Program, Garvan Institute of Medical Research, Sydney, Australia;3Institute of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria |
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Abstract: | BACKGROUND AND PURPOSEPeptide YY (PYY) and neuropeptide Y (NPY) are involved in regulating gut and brain function. Because gastrointestinal inflammation is known to enhance anxiety, we explored whether experimental colitis interacts with genetic deletion (knockout) of PYY and NPY to alter emotional-affective behaviour.EXPERIMENTAL APPROACHMale and female wild-type, NPY (NPY?/?), PYY (PYY?/?) and NPY?/?; PYY?/? double knockout mice were studied in the absence and presence of mild colitis induced by ingestion of dextran sulphate sodium (2%) in drinking water. Anxiety-like behaviour was tested on the elevated plus maze and open field, and depression-like behaviour assessed by the forced swim test.KEY RESULTSIn the absence of colitis, anxiety-like behaviour was increased by deletion of NPY but not PYY in a test- and sex-dependent manner, while depression-like behaviour was enhanced in NPY?/? and PYY?/? mice of either sex. The severity of DSS-induced colitis, assessed by colonic myeloperoxidase content, was attenuated in NPY?/? but not PYY?/? mice. Colitis modified anxiety- and depression-related behaviour in a sex-, genotype- and test-related manner, and knockout experiments indicated that NPY and PYY were involved in some of these behavioural effects of colitis.CONCLUSIONS AND IMPLICATIONSThese data demonstrate sex-dependent roles of NPY and PYY in regulation of anxiety- and depression-like behaviour in the absence and presence of colitis. Like NPY, the gut hormone PYY has the potential to attenuate depression-like behaviour but does not share the ability of NPY to reduce anxiety-like behaviour. |
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Keywords: | anxiety-like behaviour colitis corticosterone depression-like behaviour dextran sulphate sodium elevated plus maze forced swim test myeloperoxidase neuropeptide Y peptide YY |
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