| 应用平均红细胞体积测定法及红细胞脆性一管定量法筛查地？… |
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| 引用本文： | Deng J,Liu X,Liu Y. 应用平均红细胞体积测定法及红细胞脆性一管定量法筛查地？…[J]. 中华妇产科杂志, 2000, 35(10): 610-612 |
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| 作者姓名： | Deng J Liu X Liu Y |
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| 作者单位： | 中山医科大学孙逸仙纪念医院妇产科 |
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| 摘 要： | 目的 探讨平均红细胞体积（ＭＣＶ）测定法（ＭＣＶ法）及红细胞脆性一管定量法（一管法）在筛查地中海贫血中的准确性及其应用价值。方法 用ＭＣＶ法和一管法检查９８９对夫妇,并随机抽取其中７９对进行聚合酶链反应（ＰＣＲ）法检测,同时检测孕妇血清铁蛋白以排除缺铁性贫血。结果 ＭＣＶ法的轻型地中海贫血检出率为９．０％、敏感度为９８．９％,一管法的轻型地中海贫血检出率为８．１％、敏感度为８８．６％,两者比较,差
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| 关 键 词： | 地中海贫血 产前诊断 红细胞指数 红细胞体积 |
| 修稿时间： | 1999-09-18 |
Evaluation of red cell mean corpuscular volume and simple tube red cell osmotic fragility quantitative test in detection of thalassemia |
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| Deng J,Liu X,Liu Y. Evaluation of red cell mean corpuscular volume and simple tube red cell osmotic fragility quantitative test in detection of thalassemia[J]. Chinese Journal of Obstetrics and Gynecology, 2000, 35(10): 610-612 |
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| Authors: | Deng J Liu X Liu Y |
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| Affiliation: | Department of Obstetrics and Gynecology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120, China. |
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| Abstract: | OBJECTIVE: To evaluate and compare the detection efficiency of red cell mean corpuscular volume(MCV) test against simple tube red cell osmotic fragility quantitative test(STROFQT) in diagnosis of thalassemia. METHODS: 1978 subjects (989 couples) were detected by both MCV test and STROFQT, 158 samples from subjects were tested by alpha,beta-thalassemia DNA polymerase chain reaction(PCR) and serum ferritin test. RESULTS: The positive rate (9.0%), sensitivity (98.9%) of MCV test were higher than those of STROFQT (8.1%, 88.6%) (P < 0.05). The specificity of MCV test showed no statistic significance compared with that of STROFQT (P > 0.05). CONCLUSION: Both MCV test and STROFQT served as helpful approaches in detection of thalassemia, MCV test shows better diagnostic efficiency for screening than STROFQT. |
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| Keywords: | Thalassemia ? Prenatal diagnosis ? Mean corpuscular volumes |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
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