颅内外血管狭窄内支架成形术后血清超敏-C反应蛋白和白细胞介素-6的变化以及与再狭窄的关系

目的评价血清超敏C反应蛋白(hs-CRP)与白细胞介素-6(IL-6)与颅内外血管狭窄内支架成形术后再狭窄的关系。方法分析2003年~2006年25例接受内支架成形术的颅内外动脉狭窄患者,术后复查血管造影的时间为6~12个月,就术前、术后3d以及造影复查时(术后6~12个月)血清hs-CRP与IL-6的水平以及与血管再狭窄情况进行分析。结果本组25例患者,于25根血管上放置25枚支架,随访6~12个月,12/25出现了再狭窄(48%),超过50%的再狭窄为6/25,余6例再狭窄率介于10%~30%。同时监测术前以及术后血浆hs-CRP与IL-6水平,发现25例患者支架术前血浆CRP和IL-6水平在狭窄组和无狭窄组中无明显差别P>0.05;支架术后3d血清hs-CRP与IL-6水平均高于术前,统计学比较均P<0.05;术后6~12个月复查时再狭窄的12例患者血清hs-CRP与IL-6水平高于未狭窄的13例患者,两者比较有明显差别(P<0.05)。结论血清hs-CRP与IL-6与动脉硬化的炎性过程有关,两者可能参与支架术后动脉再狭窄的过程。

The relationship beween the levels of serum hs-CRP and IL-6 and the restenosis of stent-assisted angioplasty of intracranial and extracranial arteries

Objective To observe the levels of serum hs-CRP and IL-6 and the relationship beween the levels of them and the restenosis of stent-assisted angioplasty of intracranial and extracranial arteries.Methods 25 cases with cerebral artery stenosis from 2003 to 2006 were treated by stent-assistant angioplasty.The relationship was analysed between the levels of serum hs-CRP and IL-6 before and after stent-assisted angioplasty and the restenosis of cerebral artery after endovascular therapy.Results 25 patients were observed in our study,25 stents in 25 blood vessels of cerebral arteries were observed from 6 to 12 months after operation.Restenosis were seen in 12/25 of cerebral arteries (48%),and the restenosis was superior to 50 percent in 6/25.The restenosis rates in 6/25 were from 10 to 30 percent,and 13/25 vessels were kept silent during this time after operation.At the same time,the levels of serum hs-CRP and IL-6 were observed before or after operation.There was no difference of the levels of serum hs-CRP and IL-6 between the restenosis group and the non-restenosis group before operation (P>0.05).The levels of serum hs-CRP and IL-6 3d after operation were superior to those before operation respectively(P<0.05),and the levels of serum hs-CRP and IL-6 in restenosis group from 6 to 12 months after operation were superior to those in non-restenosis group(P<0.05).Conclusion The levels of serum hs-CRP and IL-6 were associated with the arterosclerotic inflammatory process,and inflammation markers maybe are relevant to the process of restenosis of cerebral artery after stent-assisted angioplasty.