Bartter综合征8例临床分析

目的探讨Bartter综合征的临床诊断及治疗。方法对8例成人Bartter综合征的临床资料进行回顾性分析。结果8例成人Bartter综合征患者均表现为乏力,其特征为低血钾,代谢性碱中毒,血清肾素活性、血管紧张素Ⅱ及醛固酮水平升高,而血压正常,肾活检提示肾小球旁器细胞增生。补钾是主要治疗措施。结论成人出现双下肢乏力,低血钾,高尿钾而血压正常时需考虑到本病,行醛固酮检测可帮助诊断,必要时行肾穿刺活检。治疗上包括补钾、补镁、醛固酮拮抗剂、前列腺素合成酶抑制剂等。

The clinical analysis of Bartter's syndrome (8 cases report)

Objective To investigate the clinical diagnosis and therapy of Bartter′s syndrome . Methods 8 cases of Bartter′s syndrome in adults were retrospectively analyzed. Results The common manifestation of eight cases of Bartter′s syndrome was fatigue. Bartter′s syndrome was characteristic of hypokalemia, metabolic alkalosis, elevations of plasma renin activity, serum angiotersin Ⅱand aldosterone and juxtaglomerular apparatus hyperplasia. Supplementation of potassium chloride was mainly the therapeutic measure. Conclusions Bartter′s syndrome should be suspected in adults with fatigue of low extremities , hypokalemia, hyperkaleura, and normal blood pressure. Aldosterone detection could help diagnosis, kidney biopsy if necessary. The therapy includes potassium supplementation ,magnesium supplementation, aldosteron antagonist, prostaglandin E synthase inhibitor,etc.