肺缺血预处理在体外循环中肺保护作用的研究

目的：探讨肺缺血预处理对体外循环中肺的保护作用及机制。方法：12只健康杂种犬随机分为实验组和对照组．每组6只。实验组（缺血预处理组）在体外循环前先用无损伤血管钳阻断右肺动脉主干5min，然后再开放10min，如此重复3次，余同单纯体外循环组即对照组。对照组在体外循环前、实验组在缺血预处理前和两组撤离体外循环机并维持循环稳定90min后，取右下肺组织标本测定丙二醛（MDA）、超氧化物歧化酶（SOD）活性及组织病理学检查。结果：肺组织含水量及MDA实验组低于对照组（P〈0．01）。肺组织SOD活性实验组高于对照组（P〈0．05）。组织学检查对照组显示肺泡阎质明显水肿，肺泡内大量的中性粒细胞渗出，实验组基本保留了正常的肺组织结构。结论：肺缺血预处理对体外循环中因全身性炎症反应及低灌注状态所致的缺血再灌注损伤。从而引起的肺组织损伤有确切的保护作用。

Protection of lung ischemic preconditioning in cardiopulmonary bypass

Objective:To explore the lung protection of ischemic preconditioning in cardiopulmonary bypass(CPB).Methods:Twelve adult mongrel dogs were randomly divided into two groups with 6 in each group.In the experimental group(ischemic preconditioning group),the right main pulmonary artery was clamped with blood vessel forceps three times with each time including five-minute clamping followed by ten-minute release,before CPB was established.The techniques of myocardium protection and cardiac arrest were the same in...