Performance characteristics of beta-2-microglobulin measurements on a Beckman Immage analyzer with the DakoCytomation reagent kit期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Performance characteristics of beta-2-microglobulin measurements on a Beckman Immage analyzer with the DakoCytomation reagent kit

Authors:	Barun K De Ernest Jimenez Soumo De

Institution:	Department of Pathology, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, P.O. Box 245059, Tucson, AZ 85724-5059, USA

Abstract:	Objective Evaluation of serum beta-2-microglobulin (β2M) in an automated analyzer. Design and methods The DakoCytomation β2M kit is an antibody based reagent intended for quantitative determination of β2M in serum and plasma by rate nephelometry. Results The limit of blank is 0.16 mg/L. The method is linear up to 17.9 mg/L. The imprecision ranged from 2.1% to 7.9% at the concentrations of 1.77 and 7.19 mg/L, respectively. Method comparison yielded slope = 1.009, r = 0.998. No interference was observed from hemolytic or icteric specimens. Reference interval of a healthy population was 1.13 mg/L to 3.04 mg/L. Conclusion The DakoCytomation reagent is acceptable to measure serum β2M.

Keywords:	Beta-2-microglobulin Tumor marker DakoCytomation Rate nephelometry
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