自杀未遂与5-羟色胺2A受体基因的关联分析

目的 探讨5-羟色胺（5-HT）2A受体基因A-1438G和T102C两种多态性与自杀未遂之间的关系。方法 以149例自杀未遂者为研究对象。190名正常人为对照，采用聚合酶链反应-限制性片段长度多态性（polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)方法，分析5-HT2A受体基因A-1438G和T102C多态性。结果 PCR-RFLP分析发现，男性自杀未遂与5-HT2A受体基因A-1438G多态性的基因型GG关联。结论 5-HT2A受体基因A-1438G多态性可能与男性的自杀易感性相关。

Association analysis of attempted suicide and 5-HT2A receptor gene

Objective To examine the relationship of attempted suicide with A 1438G and T102C polymorphisms of 5 HT2A receptor gene. Methods Genotypes and allele frequencies of A 1438G and T102C polymorphisms of 5 HT2A receptor gene in 149 attempted suicides and 190 normal controls were examined by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP). Results No differences in genotypes and allele frequencies of A 1438G and T102C polymorphisms of 5 HT2A receptor gene were observed between attempted suicides and the controls. However, an association between male attempted suicides and genotype(GG) of A 1438G polymorphism was found. Conclusion These results suggested that liability to suicide behavior might be associated with A 1438G polymorpyhism of 5 HT2A receptor gene in male subjects.