Inhibitory effects of Okbyungpoong-Gamhmi on anaphylactic responses |
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Authors: | Hong Seung-Heon Yi Jin-Mu Kim Hongjun Choi Ho-Young Kim Yun-Kyung Chae Han-Jung Kim Hyung-Ryong Kim Cheorl-Ho Kim Hyung-Min |
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Institution: | Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 570-749, Republic of Korea. |
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Abstract: | We investigated the effect of a herbal formulation Okbyungpoong-Gamhmi (OG) on mast cell-dependent anaphylactic reactions by intra-rectal administration. OG concentration dependently inhibited compound 48/80-induced anaphylaxis-like response and ear swelling response with doses of 0.01-1g/kg. OG also inhibited the passive cutaneous anaphylaxis at the same concentrations. The histamine release induced by compound 48/80 or IgE from the rat peritoneal mast cells was reduced by 64.2 and 63.6%, respectively, at 1g/l. These results provide evidence that intra-rectal therapy of OG may be beneficial in the treatment of anaphylactic response. |
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