新冠心苏合活血方辨治慢性稳定型心绞痛的疗效及对ROS,Periostin,CT-1的影响

目的:探讨新冠心苏合活血方辨治慢性稳定型心绞痛(SAP)的疗效及对血清中活性氧物质(ROS),骨膜蛋白(periostin),心肌营养素-1(CT-1)的影响作用。方法:选自SAP患者118例,按照数字表法随机分为对照组和观察组各59例。对照组组患者参见《慢性稳定型心绞痛诊断与治疗指南》予西医常规干预。观察组在对照组治疗的基础上给予新冠心苏合活血方,1剂/次,2次/d;两组均连续治疗12周。比较两组阴寒凝滞证症状评分、心绞痛发作情况、西雅图心绞痛量表(SAQ)生活质量评分及临床疗效。全自动生化分析仪测定两组治疗前后血脂水平;检测两组血清中ROS,periostin,CT-1水平。结果:观察组治疗后与对照组比较,加用新冠心苏合活血方患者阴寒凝滞证症状评分、绞痛发作次数和心绞痛持续时间减少更具明显,SAQ生活质量各维度评分提高更显著(P0.01)。观察组患者总有效率为93.1%,对照组为77.19%,观察组优于对照组(P0.05)。治疗后,观察组与对照组比较,患者的甘油三酯(TG),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C)水平降低均更明显,高密度脂蛋白胆固醇(HDL-C)提高更为显著(P0.01);治疗后观察组血清中ROS,periostin,CT-1水平均明显低于对照组(P0.01)。结论:新冠心苏合活血方辨治阴寒凝滞型慢性SAP,可改善患者的中医临床症状和生活质量,减少心绞痛发作程度,提高临床疗效,抑制机体内ROS,periostin,CT-1水平可能是其疗效途径之一。

Efficacy of New Guanxin Suhe Huoxue Decoction in Treating Chronic Stable Angina Pectoris and on ROS, Periostin and CT-1 Effects

Objective: To investigate the efficacy of new Guanxin Suhe Huoxue decoction in treating chronic stable angina pectoris (SAP) with syndrome of cold and cold stagnation and observe its effect on serum levels of reactive oxygen species (ROS), periostin and cardiotrophin-1 (CT-1).Method: One hundred and eighteen patients with chronic SAP were selected and randomly divided into control group 59 cases and observation group 59 cases. Both groups received routine western medicine according to Guideline for Diagnosis and Treatment of Chronic Stable Angina. Observation group was also given with new Guanxinsuhe Huoxue decoction, 1 dose/time, bid. Both groups were treated for 12 weeks. Symptom scores of syndrome of cold and cold stagnation, attack frequency and degree of angina pectoris, quality of life scores in Seattle Angina Questionnaiire (SAQ), and efficacy were compared between two groups. Blood lipid levels were detected in both groups by fully automatic biochemical analyser before and after treatment; and the serum levels of ROS, periostin and CT-1 were also measured in two groups.Result: As compared to control group, the symptom scores of syndrome of cold and cold stagnation, frequency of angina pectoris, and attack duration of angina pectoris were significantly reduced, while scores of SAQ life quality indexes were obviously increased in patients with new Guanxinsuhe Huoxue decoction (P<0.01). The total efficacy was 93.1% in observation group better than 77.19% in control group (P<0.05). After treatment, as compared to control group, the levels of triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in observation group were obviously decreased, while high-density lipoprotein cholesterol (HDL-C) was higher (P<0.01). Serum levels of ROS, periostin, and CT-1 in the observation group were evidently lower than those in control group (P<0.01).Conclusion: New Guanxin Suhe Huoxue decoction can improve clinical symptoms of traditional Chinese medicine and life quality, alleviate the degree of angina pectoris attacks, and increase efficacy in treating chronic stable angina pectoris with cold and cold stagnation syndrome. One of its mechanisms may be associated with inhibiting levels of ROS, periostin and CT-1.