盐酸帕洛诺司琼麻醉诱导前给药缓解罗库溴铵注射痛

目的 探究盐酸帕洛诺司琼在全身麻醉手术中诱导前给药对罗库溴铵注射痛的缓解效果及与地佐辛疗效差异。方法 2016年12月~2017年3月于笔者医院行经口插管全身麻醉下择期手术的患者150例，采用数字表法随机分为3组，即帕洛诺司琼组（Pal组）、地佐辛组（Dez组）、安慰剂组（Con组），每组各50例。麻醉诱导前，Pal组患者静脉注射盐酸帕洛诺司琼0.25mg，Dez组注射地佐辛5mg，Con组注射5ml生理盐水，咪达唑仑镇静后，快速推注1%罗库溴铵0.6mg/kg。观察3组患者罗库溴铵注射前Ramsay评分，注射后四肢退缩反应评级、平均血压（MAP）、心率（HR），记录术后苏醒时间及清醒后1h不良反应。结果 Pal组和Dez组四肢退缩反应评级明显低于Con组（P<0.05）。Pal组肢缩反应评级明显低于Dez组（P<0.05）。3组患者罗库溴铵注射后Ramsay评分、MAP、HR、术后苏醒时间差异无统计学意义（P>0.05）。Pal组无恶心、呕吐、寒战、头晕、头疼等不适。结论 盐酸帕洛诺司琼在全身麻醉手术中诱导前给药能有效缓解罗库溴铵注射痛，不干扰麻醉效果及血流动力学，安全有效。

Pretreatment of Palonosetron Hydrochloride in General Anesthesia Induction to Prevent Injection Pain of Rocuronium Bromide

Objective To explore the relieving effect of rocuronium injection pain by palonosetron hydrochloride injection in general anesthesia induction,and therapeutic difference compare with dezocine. Methods Totally 150 patients treated with oral intubation under general anesthesia from December 2016 to March 2017 in our hospital were randomly devided into 3 groups:Palonosetron group (Pal group), dezocine group (Dez group) and placebo group (Con group). Each group had 50 cases. Before induction of anesthesia, group Pal received palonosetron hydrochloride 0.25mg;group Dez received dezocine 5mg;Con group received 5ml saline.After midazolam sedation, patients were rapidly injected with rocuronium 1% 0.6mg/kg. We observed the Ramsay score of patients in 3 groups before rocuronium and the limb withdrawal score, average blood pressure (MAP) and heart rate (HR) after injection. And we recorded the postoperative recovery time and adverse reaction 1h after waking. Results The limb withdrawal score in Pal group and Dez group were significantly lower than those in Con group (P<0.05). And the limb withdrawal score of Pal group was significantly lower than that of Dez group (P<0.05). There was no significant difference in Ramsay score, MAP, HR and postoperative recovery time between the 3 groups (P>0.05). There was no nausea, vomiting, chills, dizziness and headache in Pal group. Conclusion Pretreatment with Palonosetron hydrochloride can effectively relieve the pain of injection with rocuronium, without interfering anesthesia effect and hemodynamics, safe and effective.