| 阿朴菲类生物碱研究进展 |
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| 引用本文： | 辛爱一,柳军玺,邸多隆.阿朴菲类生物碱研究进展[J].中草药,2018,49(3):712-724. |
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| 作者姓名： | 辛爱一 柳军玺 邸多隆 |
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| 作者单位： | 中国科学院兰州化学物理研究所, 中国科学院西北特色植物资源化学重点实验室, 甘肃省天然药物重点实验室, 甘肃 兰州 730000;中国科学院大学, 北京 100049,中国科学院兰州化学物理研究所, 中国科学院西北特色植物资源化学重点实验室, 甘肃省天然药物重点实验室, 甘肃 兰州 730000,中国科学院兰州化学物理研究所, 中国科学院西北特色植物资源化学重点实验室, 甘肃省天然药物重点实验室, 甘肃 兰州 730000 |
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| 基金项目： | 国家自然科学基金资助项目（21672225） |
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| 摘 要： | 阿朴菲类生物碱是异喹啉类生物碱中的一类,具有广泛的生理学活性,目前这类天然产物及其衍生物是发现治疗多种疾病药物的先导化合物和研究热点。通过对国内外文献调研,从自然界植物资源分布、生源合成途径、天然有机合成方法、药理活性等方面的研究进展进行综述,为阿朴菲类生物碱的进一步研究和深层次开发提供参考依据。
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| 关 键 词： | 阿朴菲类生物碱 植物资源分布 生源合成 天然有机合成 异喹啉生物碱 |
| 收稿时间： | 2017/7/13 0:00:00 |
Research progress on aporphine alkaloids |
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| XIN Ai-yi,LIU Jun-xi and DI Duo-long.Research progress on aporphine alkaloids[J].Chinese Traditional and Herbal Drugs,2018,49(3):712-724. |
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| Authors: | XIN Ai-yi LIU Jun-xi and DI Duo-long |
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| Institution: | CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;University of Chinese Academy of Sciences, Beijing 100049, China,CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China and CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
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| Abstract: | Aporphine alkaloids belong to isoquinoline alkaloids and have a wide range of physiological activities. These natural products and their derivatives are the lead compound of the novel drug for the treatment of various diseases. Based on many literatures, the plant distribution, biosynthetic pathways, natural organic synthesis methods and pharmacological activities of those aporphine alkaloids have been summarized in this paper, which would supported the deeply development about the pharmaceutical research based on the aporphine alkaloids. |
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| Keywords: | aporphine alkaloids plant resource distribution biosynthetic pathways natural organic synthesis isoquinoline alkaloids |
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