比较PET/CT显像中肝脏18F-FDG摄取半定量分析方法

目的 探讨PET/CT显像中影响肝脏¹⁸F-FDG摄取的因素，分析常规体质量（BM）、瘦体质量（LBM）及体表面积（BSA）校正最大标准化摄取值（SUV_max-B、SUV_max-L、SUV_max-S）的应用价值。方法 回顾性分析行¹⁸F-FDG PET/CT显像的67名健康受检者。测量肝脏SUV_max-B、SUV_max-L及SUV_max-S，分析年龄、空腹血糖水平、体质量指数（BMI）、肝脏CT值、性别、脂肪肝对上述参数的影响。结果 空腹血糖水平与肝脏SUV_max-B、SUV_max-L、SUV_max-S均呈正相关（r=0.329、0.336、0.353，P=0.012、0.010、0.007）。BMI与肝脏SUV_max-B （r=0.543，P<0.01）、SUV_max-L （r=0.328，P=0.07）呈正相关BMI与SUV_max-S无相关性（r=0.026，P=0.833）。受检者年龄、肝脏CT值与肝脏SUV_max-B、SUV_max-L、SUV_max-S均无相关性（P均>0.05）。男性肝脏SUV_max-B （t=2.608，P=0.011）、SUV_max-L （t=5.272，P<0.001）明显高于女性，男性与女性肝脏SUV_max-S无统计学差异（t=0.759，P=0.450）。脂肪肝受检者与非脂肪肝受检者肝脏SUV_max-B、SUV_max-L、SUV_max-S均无统计学差异（P=0.646、0.775、0.068）。结论 空腹血糖水平、BMI、性别是PET/CT显像中影响肝脏摄取¹⁸F-FDG的因素。BMI较大的受检者可采用SUV_max-L或SUV_max-S代替SUV_max-B，此外SUV_max-S可弥补性别间的差异，但校正技术无法减弱血糖水平对肝脏SUV_max的影响。

Comparison on semi-quantitative analysis methods of liver 18F-FDG uptake in PET/CT imaging

Objective To explore the impact factors of liver uptake of ¹⁸F-FDG in PET/CT imaging, and to preliminary analyze the application of maximum standardized uptake values corrected by conventional body mass, lean body mass and body surface area (SUV_max-B, SUV_max-L, SUV_max-S).Methods A retrospective analysis was performed on 67 healthy subjects who underwent ¹⁸F-FDG PET/CT. SUV_max-B, SUV_max-L and SUV_max-S were measured, and the impact of age, levels of fasting blood glucose, body mass index (BMI), CT value of liver, gender and the fatty liver on SUV_max-B, SUV_max-L and SUV_max-S were analyzed.Results The liver SUV_max-B, SUV_max-L, SUV_max-S were positively correlated with the levels of fasting blood glucose (r=0.329, 0.336, 0.353, P=0.012, 0.010, 0.007). There was a positive correlation between BMI and SUV_max-B (r=0.543, P<0.01), SUV-L (r=0.328, P=0.007), while BMI value had no correlation with SUV_max-S (r=0.026, P=0.833). There was no correlation between age, CT value of the liver nor SUV_max-B, SUV_max-L and SUV_max-S (all P>0.05). The liver SUV_max-B (t=2.608, P=0.011) and SUV_max-L (t=5.272, P=0.001) of male were significantly higher than those of female, while there was no difference between male''s and female''s liver SUV_max-S and liver SUV_max-S (t=0.759, P=0.450). There was no difference in SUV_max-B, SUV_max-L nor SUV_max-S between fatty liver subjects and non-fatty liver subjects (P=0.646, 0.775, 0.068).Conclusion The fasting blood glucose level, BMI and sex are the impact factors of liver uptake of ¹⁸F-FDG in PET/CT imaging. SUV_max-B can be replaced by SUV_max-L or SUV_max-S for larger BMI subjects, while SUV_max-S can make up differences between different genders. However, correction techniques can not weaken the impact of blood glucose level on SUV_max value of liver.