| 肺癌患者治疗前后血清白细胞介素-6、肿瘤坏死因子和血管内皮生长因子水平及其临床意义 |
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| 引用本文： | 柳兴其,陈检芳.肺癌患者治疗前后血清白细胞介素-6、肿瘤坏死因子和血管内皮生长因子水平及其临床意义[J].中国现代医学杂志,2006,16(18):2776-2778. |
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| 作者姓名： | 柳兴其 陈检芳 |
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| 作者单位： | 1. 中南大学湘雅二医院,检验科,湖南,长沙,410011
2. 中南大学现代分析测试中心实验核医学研究室,湖南,长沙,410078 |
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| 摘 要： | 目的 探讨肺癌患者治疗前后血清IL-6、TNF、VEGF水平的变化及临床意义。方法 采用酶联免疫吸附法和放射免疫分析法分别测定了98例肺癌患者血清IL-6、TNF、VEGF含量水平，并与60例正常健康人作比较。结果 化疗前肺癌患者血清IL-6、TNF、VEGF含量水平均显著地高于正常人（P〈0．01）。结论 测定肺癌患者血清IL-6、TNF、VEGF水平，对其病情了解、疗效观察、判断预后都具有极其重要的临床价值。
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| 关 键 词： | 肺癌 白细胞介素-6 肿瘤坏死因子 血管内皮生长因子 |
| 文章编号： | 1005-8982（2006）18-2776-03 |
| 收稿时间： | 2006-05-07 |
| 修稿时间： | 2006-05-07 |
Clinical significance of determination of changes of serum IL-6, TNF and VEGF levels after treatment in patients with lung cancer |
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| LIU Xing-qi,CHEN Jian-fang.Clinical significance of determination of changes of serum IL-6, TNF and VEGF levels after treatment in patients with lung cancer[J].China Journal of Modern Medicine,2006,16(18):2776-2778. |
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| Authors: | LIU Xing-qi CHEN Jian-fang |
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| Institution: | 1.Department of Laboratory, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R.China; 2.Research Laboratory of Experimental Nuclear Medicine, Modern Analytical Testing Center, Central South University, Changsha, Hunan 410078, P.R. China |
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| Abstract: | Objective] To detect the clinical significance of changes of serum IL-6,TNF and VEGF levels after treatment in 98 patients with lung cancer.Methods] Serum IL-6,TNF(with RIA)and VEGF(with ELISA)contents were determined both before and after treatment in 76 patients with lung cancer as well as in 60 controls.Results] Before treatment,serum IL-6,TNF and VEGF levels in the patients were significantly higher than those in the controls(P <0.01).Conclusion] The changes of levels of serum IL-6,TNF and VEGF were closely related to the disease status and was of prognostic value in lung cancer. |
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| Keywords: | lung cancer interleukin-6(IL-6) tumor necrosis factor(TNF) vascular endothelial growth factor(VEGF) |
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