In vitro activities at pH 5.0 and pH 7.0 and in vivo efficacy of flucytosine against Aspergillus fumigatus |
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| Authors: | Verweij Paul E Te Dorsthorst Debbie T A Janssen Willem H P Meis Jacques F G M Mouton Johan W |
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| Affiliation: | Department of Medical Microbiology, Radboud University Nijmegen Medical Center, P.O. Box 9101, Nijmegen 6500 HB, The Netherlands. p.verweij@mmb.umcn.nl |
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| Abstract: | The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis. |
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