| 手性药物拆分技术的研究进展 |
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| 引用本文： | 卢定强,李衍亮,凌岫泉,涂清波,陈佳.手性药物拆分技术的研究进展[J].时珍国医国药,2009,20(7). |
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| 作者姓名： | 卢定强 李衍亮 凌岫泉 涂清波 陈佳 |
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| 作者单位： | 1. 南京工业大学药学院,江苏,南京,210009;江苏省药物研究所,江苏,南京,210009
2. 南京工业大学药学院,江苏,南京,210009 |
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| 摘 要： | 简要阐述了手性药物的世界销售市场.综述了目前实验室和工业生产领域手性药物的拆分方法,包括:结晶拆分法,化学拆分法,动力学拆分法,生物拆分法,色谱拆分法,手性萃取拆分法和膜拆分法等,并简要介绍了每种方法的应用情况及优缺点.
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| 关 键 词： | 手性药物 外消旋体 手性拆分 |
Technical Progress on the Chiral Drug Resolutions |
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| LU Ding-qiang,LI Yan-liang,LING Xiu-quan,TU Qing-bo,CHEN Jia.Technical Progress on the Chiral Drug Resolutions[J].Lishizhen Medicine and Materia Medica Research,2009,20(7). |
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| Authors: | LU Ding-qiang LI Yan-liang LING Xiu-quan TU Qing-bo CHEN Jia |
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| Abstract: | In this paper,the global market of chiral drugs were summarized.Chiral resolution techniques were briefly reviewed according to recent references,both those already in commercial practice and emerging technologies in labs,including crystallization,chemical,ferment,chromatographic,chiral extraction and membranous.The merit and defect of every methods were discussed. |
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| Keywords: | Chiral drug Raceme Chiral separation |
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