Synthesis and purification of 2-deoxy-2-[18F]fluoro-d-glucose and 2-deoxy-2-[18F]fluoro-d-mannose: characterization of products by 1H- and 19F-NMR spectroscopy |
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| Affiliation: | 1. Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Via E. Orabona 4, 70125 Bari, Italy;2. Itel Telecomunicazioni srl - Radiopharmaceutical Business Unit, Via Antonio Labriola lotto 39 z.i., 70037 Ruvo di Puglia (BA), Italy |
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| Abstract: | A procedure has been developed that allows the separation of 2-deoxy-2-[18F]fluoro-d-glucose from 2-deoxy-2-[18F]fluoro-d-mannose employing selectively optimized ion-moderated partition chromatography. Both compounds can be obtained with a >98% chemical and radiochemical purity in about one half-life of 18F. Both the α- and β-anomers of both sugars were completely characterized by high-resolution 1H- and 19F-NMR spectroscopy. Various convenient preparation methods for 2-deoxy-2-[18F]fluoro-d-glucose were compared. |
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