| 老年期抑郁症患者海马磁共振质子波谱研究 |
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| 引用本文： | 许云,刘文,梅刚,马清,李海林,陈宁.老年期抑郁症患者海马磁共振质子波谱研究[J].临床精神医学杂志,2009,19(4). |
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| 作者姓名： | 许云 刘文 梅刚 马清 李海林 陈宁 |
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| 作者单位： | 南京医科大学附属脑科医院,210029 |
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| 基金项目： | 南京医科大学科技发展项目(编号:NY04060) |
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| 摘 要： | 目的:探讨老年期抑郁症患者海马的磁共振质子波谱(1H-MRS)特点。方法:应用1H-MRS成像技术检测11例晚发性抑郁症患者(患者组)予文拉法辛缓释剂治疗6周前后两侧海马头、体、尾部N-乙酰天门冬氨酸(NAA)、胆碱(Cho)和肌酸(Cr)3种代谢物,计算NAA/Cr和Cho/Cr比值。并且与15名健康对照者(对照组)的检测结果进行比较。结果:治疗前后患者组右侧海马头部NAA和Cho含量及左侧海马头部Cho含量均显著低于对照组(P<0.05或P<0.01)。患者组右侧海马头部Cho/Cr治疗前显著低于对照组(P<0.05),治疗后较治疗前显著升高(P<0.05),并且与对照组的差异无显著统计学意义(P>0.05)。患者组右侧海马体部Cho含量治疗前显著低于对照组(P<0.05),治疗后右侧海马体部NAA/Cr和Cho/Cr显著高于治疗前,与对照组的差异无显著统计学意义(P>0.05)。结论:老年期抑郁症患者可能存在左右两侧海马头部细胞膜代谢异常,右侧海马头部神经元活力下降。
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| 关 键 词： | 抑郁症 海马 磁共振波谱学 文拉法辛缓释剂 |
A 1H-magnetic resonance spectroscopy study on hippocampus in patients with geriatric depression |
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| XU Yun,LIU Wen,MEI Gang,MA Qing,LI Hai-lin,CHEN Ning.A 1H-magnetic resonance spectroscopy study on hippocampus in patients with geriatric depression[J].Journal of Clinical Psychological Medicine,2009,19(4). |
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| Authors: | XU Yun LIU Wen MEI Gang MA Qing LI Hai-lin CHEN Ning |
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| Institution: | XU Yun,LIU Wen,MEI Gang,MA Qing,LI Hai-lin,CHEN Ning.Brain Hospital Affiliated to Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective:To explore the characteristics of 1H-magnetic resonance spectroscopy(1H-MRS)on hippocampus in patients with geriatric depression.Method:11 patients with geriatric depression(patient group)were conducted 1H-MRS to measure three metabolites,including N-acetyl-aspartate(NAA),choline phosphate(Cho)and creatinine(Cr),and the ratios of NAA /Cr and Cho /Cr on the two sides of hippocampus' head,body and caudal,before and after 6-week treatment with valfaxine-sustained release(valfaxine-SR),compared with 1... |
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| Keywords: | depression hippocampus magnetic resonance spectroscopy valfaxine-sustained release |
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